Formulation and Evaluation of Besifloxacin Loaded in Situ Gel for Ophthalmic Delivery

Optimization and evaluation of a thermoresponsive ophthalmic in situ gel containing curcumin-loaded albumin nanoparticles

This study aimed to optimize and evaluate a thermoresponsive ophthalmic in situ gel containing curcumin-loaded albumin nanoparticles (Cur-BSA-NPs-Gel). Albumin nanoparticles were prepared via a desolvation method, and the gels were prepared via a cold method. The central composite design and response surface method was used to evaluate the effects of varying Pluronic F127 and Pluronic F68 conce...

Formulation and Evaluation of in Situ Mucoadhesive Ophthalmic Hydrogel for Sustained Delivery of Pefloxacin Mesylate

Objective: The drawback associated with conventional eye drops needs development of novel ophthalmic delivery system with improved bioavailability and patient compliances. The objective of present work was to develop and evaluate mucoadhesive in situ ocular gel of Pefloxacin mesylate based on the concept of ion activated in situ gelation for the prolonged precorneal residence time. Methods: For...

Formulation and In-Vitro Evaluation of Fluconazole Loaded Microsponge Gel For Topical Sustained Delivery

The objective of present work was to formulate and evaluate Fluconazole (FLZ) microsponges using quasi emulsion solvent diffusion technique and microsponge gel by using carbopol. Microsponges containing FLZ were obtained successfully with different proportions of ethyl cellulose polymer (EC). The formulations were studied for particle size and physical characterization. The physical characteriz...

Preparation and characterization of bear bile-loaded pH sensitive in-situ gel eye drops for ocular drug delivery

Objective(s): In this study, a stable bear bile-loaded pH sensitive in-situ eye drop gel was prepared for sustain delivery and enhanced therapeutic application. Materials and Methods: Bear bile-loaded in-situ ocular gels with different Carbopol/Hydroxypropyl methylcellulose (HPMC)  ratios were prepared and their stability was tested in P...

Development and Evaluation of Carbamazepine Loaded Transfersomal In-situ Gel for Nose to Brain Delivery